Control of Monocyte Morphology on and Response to Model Surfaces for Implants Equipped with Anti-Inflammatory Agent


  • This work was supported by the Ligue contre le Cancer (Région Alsace). N. B.-J. is indebted to the Faculté de Chirurgie Dentaire of Strasbourg for financial support. The authors are indebted to Jerôme Mutterer (Institut de Biologie Moléculaire des Plantes, Strasbourg, France) for assistance with the CLSM. The CLSM platform used in this study was co-financed by the Région Alsace, the CNRS, the Université Louis Pasteur, and the Association pour la Recherche sur le Cancer.


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In order to prevent local chronic inflammation due to biomaterials such as implants, surface coatings that are able to modulate inflammatory response have been developed. It is shown that polyelectrolyte multilayers containing alpha-melanocyte-stimulating hormone (α-MSH) can be advantageously used for this purpose. The presence of α-MSH has been demonstrated to induce cellular responses that can be modulated by varying the film architecture (see Figure).