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Advanced Materials

Porous Polymer and Cell Composites That Self-Assemble In Situ

Authors


  • The authors acknowledge the BBSRC and EPSRC for support.

Abstract

A cell-laden 3D network is formed upon the addition of avidin to biotinylated polymer particles in the presence of a suspension of cells (see Figure). Applications in tissue engineering and drug delivery are demonstrated; a shape-retaining biomaterial is formed within minutes of injecting the components into a cavity. The molecular interaction mechanism of self-assembly differentiates this polymer/cell composite from other injectable systems.

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