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Keywords:

  • Alginate;
  • Crosslinking;
  • Degradation;
  • Hydrogels
Thumbnail image of graphical abstract

The degradation rates of hydrogels are shown to be regulated by the modulation of the dissociation rates of the polymer chains via a size mismatch in the crosslinking zones. This method (used to control degradation) can be exploited in order to engineer cartilage tissue in vivo (see Figure).