Biomimetic Coating of Laminin–Apatite Composite on Titanium Metal and Its Excellent Cell-Adhesive Properties


  • This work was supported in part by the Industrial Technology Technician and Researcher Fellowship Program in 2002 from the New Energy and Industrial Technology Development Organization (NEDO) and a Grant-in-Aid for Scientific Research for Young Scientists in 2003 from the Ministry of Education, Culture, Sports and Technology, Japan (to M. U.).


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A laminin–apatite composite layer (see Figure) with superior cell-adhesion properties that has been formed on the surface of titanium metal without denaturation of the laminin is reported. Application of the composite to titanium materials is expected to prevent bacterial infection, and it is therefore believed that this material could be useful for percutaneous implants, such as artificial tooth roots or skin terminals.