Communication

Enzymatic Formation of Supramolecular Hydrogels†

  1. Z. Yang1,
  2. H. Gu1,
  3. D. Fu1,
  4. P. Gao3,
  5. J. K. Lam1,
  6. B. Xu2

Article first published online: 2 SEP 2004

DOI: 10.1002/adma.200400340

Issue

Advanced Materials

Advanced Materials

Volume 16, Issue 16, pages 1440–1444, August, 2004

Additional Information

How to Cite

Yang, Z., Gu, H., Fu, D., Gao, P., Lam, J. K. and Xu, B. (2004), Enzymatic Formation of Supramolecular Hydrogels. Adv. Mater., 16: 1440–1444. doi: 10.1002/adma.200400340

Author Information

  1. 1

    Department of Chemistry, The Hong Kong University of Science & Technology, Clear Water Bay, Hong Kong, P.R. China

  2. 2

    Bioengineering Program, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, P.R. China

  3. 3

    Department of Chemical Engineering, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, P.R. China

  1. †

    The authors acknowledge Hong Kong Research Grant Council, The Hong Kong University of Science Technology (EHIA), and E. I. DuPont Co. (Young Faculty Award to BX) for their financial support. We thank Ms. Pauline S. T Leung for help with rheology testing.

Publication History

  1. Issue published online: 2 SEP 2004
  2. Article first published online: 2 SEP 2004
  3. Manuscript Accepted: 17 MAY 2004
  4. Manuscript Received: 7 MAR 2004
Corrected by:

Correction: Enzymatic Formation of Supramolecular Hydrogels

Vol. 18, Issue 5, 545, Article first published online: 2 MAR 2006

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Keywords:

  • Biomaterials;
  • Enzymes;
  • Hydrogels;
  • Sol–gel processes
Thumbnail image of graphical abstract

The enzymatic formation of supramolecular hydrogels is reported. A dephosphorylation enzymatic reaction (see Figure) triggers the self-assembly of N-(fluorenyl-methoxycarbonyl) tyrosine and results in hydrogelation at physiological temperatures. This enzymatic gelation process offers opportunities for in-situ generation of hydrogels in tissues and demonstrates potential for biomedical applications of supramolecular hydrogels.

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