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Enzymatic Formation of Supramolecular Hydrogels



This article is corrected by:

  1. Errata: Enzymatic Formation of Supramolecular Hydrogels Volume 18, Issue 5, 545, Article first published online: 2 March 2006

  • The authors acknowledge Hong Kong Research Grant Council, The Hong Kong University of Science Technology (EHIA), and E. I. DuPont Co. (Young Faculty Award to BX) for their financial support. We thank Ms. Pauline S. T Leung for help with rheology testing.


The enzymatic formation of supramolecular hydrogels is reported. A dephosphorylation enzymatic reaction (see Figure) triggers the self-assembly of N-(fluorenyl-methoxycarbonyl) tyrosine and results in hydrogelation at physiological temperatures. This enzymatic gelation process offers opportunities for in-situ generation of hydrogels in tissues and demonstrates potential for biomedical applications of supramolecular hydrogels.

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