We thank Dr. S. A. Davis for help with TEM investigations and EPSRC for financial support. Supporting Information is available online from Wiley InterScience or from the author.
Fabrication of Protein/Silica Core–Shell Nanoparticles by Microemulsion-Based Molecular Wrapping†
Article first published online: 8 NOV 2004
Copyright © 2004 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Volume 16, Issue 20, pages 1838–1841, October, 2004
How to Cite
Ma, D., Li, M., Patil, A. J. and Mann, S. (2004), Fabrication of Protein/Silica Core–Shell Nanoparticles by Microemulsion-Based Molecular Wrapping. Adv. Mater., 16: 1838–1841. doi: 10.1002/adma.200400351
- Issue published online: 8 NOV 2004
- Article first published online: 8 NOV 2004
- Manuscript Accepted: 22 JUN 2004
- Manuscript Received: 9 MAR 2004
- Biomolecular encapsulation;
- Core–shell particles;
- Molecular wrapping;
A novel process for wrapping individual myoglobin molecules with an ultrathin shell of silica is reported. Confinement of single protein molecules in microemulsion water droplets followed by the controlled hydrolysis and condensation of tetramethoxysilane at the oil/water interface produces discrete protein/ silica nanoparticles (see Figure) without loss of myoglobin structure and function.