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Synthesis of a Dendritic Core–Shell Nanostructure with a Temperature-Sensitive Shell


  • This research was supported by the Science and Natural Foundation of China, Grant Nos. 50403015 and 20404003. Supporting Information is available online from Wiley InterScience or from the autor.


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Temperature-sensitive core–shell nanostructures are synthesized by functionalizing a hydroxyl-terminated dendrimer with a reversible addition-fragmentation chain transfer (RAFT) polymerization chain-transfer agent. RAFT polymerization of N-isopropylacrylamide produces a shell around the dendrimer (see Figure). In aqueous solution, changing the temperature by 10 °C can reversibly open and close the poly(N-isopropylacrylamide) shell. Entrapment and temperature-induced liberation of pyrene from the nanostructures is demonstrated.

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