Electroactive Substrates that Reveal Aldehyde Groups for Bio-Immobilization


  • This work was supported by the National Science Foundation and the Army Research Office.


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An electroactive substrate (see Figure) that reveals aldehyde groups in response to an oxidative potential is reported. The process is based on monolayers that can be switched to initiate the selective immobilization of an amino functionalized ligand, and marks a significant advance over previous dynamic substrates that have initiated the immobilization of a ligand, since it reveals a functional group that does not require labelling of a ligand.