Controlled Assembly of Protein–Nanoparticle Composites through Protein Surface Recognition


  • This research was supported by the National Institutes of Health (NIH, GM 62998) and the National Science Foundation (NSF, CHE-0213354, and MRSEC facilities). We acknowledge Nicholas O. Fischer for figure preparations. B. L. F. acknowledges the ACS Division of Organic Chemistry Graduate Fellowship sponsored by the Proctor and Gamble Company. Supporting Information is available online from Wiley InterScience or from the author.


original image

Controlled assembly of protein–nanoparticle composites through complementary protein surface recognition is demonstrated. Interaction of an unstable protein (chymotrypsin) with a gold nanoparticle results in close interparticle spacing, while a stable protein (cytochrome C) that retains its structure upon binding produces a hybrid material with a larger interparticle distance (see Figure).