Thermogelling Multiblock Poloxamer Aqueous Solutions with Closed-Loop Sol–Gel–Sol Transitions on Increasing pH


  • This work was supported by a Korea Research Foundation grant (KRF-2002-015-CP0275).


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A closed-loop sol–gel–sol transition is reported for aqueous solutions of a multiblock polyoxamer. The combination of ionizable carboxylic acid groups and water-soluble poly(ethylene glycol) units balance each other to form a gel phase between pH 4 and 6 (see Figure).