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Advanced Materials

pH-Triggered Thermally Responsive Polymer Core–Shell Nanoparticles for Drug Delivery

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  • This work was funded by Institute of Bioengineering and Nanotechnology, Agency for Science, Technology and Research, Singapore. Supporting Information is available online from Wiley InterScience or from the author.

Abstract

Novel polymer core–shell nanoparticles that exhibited a pH-dependent lower critical solution temperature (LCST) have been synthesized. The nanoparticles displayed stable structure in a nominal physiological environment but deformed and precipitated in an acidic environment, thereby releasing the enclosed drug molecules (see Figure). The nanoparticles would make a promising carrier for targeting drugs to tumor tissues or cell interiors where the environment is characteristically acidic.

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