Microarrays of Peptide Fibrils Created by Electrostatically Controlled Deposition

Authors


  • We thank Prof. Mike Horton (UCL Medicine), Prof. Gabriel Aeppli (UCL Physics), Sarah Harris (UCL Physics), and Monica Ritco-Vonsovici (UCL Medicine) for fruitful discussions and support. We thank Wilhelm Huck and Guillaume Fichet (Cambridge, Chemistry) for providing PDMS stamps. This research is funded by the Interdisciplinary Research Collaboration (IRC) for Nanotechnology and further supported by the London Centre for Nanotechnology (LCN). R. A. M. is a Dorothy Hodgkin Royal Society Research Fellow and C. E. M. is a Royal Society University Research Fellow.

Abstract

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The adsorption of β-sheet-rich fibrils produced in vitro via the self-assembly of polypeptides onto surfaces is found to be governed by electrostatic interactions. Chemically patterned substrates are used to create lateral micropatterns of fibrils and hybrid microstructures of fibrils with inorganic nanoparticles (see Figure). β-sheet-rich fibrils are promising as functional biomaterials.

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