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Advanced Materials

Freeze-Drying of Soft Nanoparticles with Projection Coronas Forms Three-Dimensional Microconstructs

Authors

  • T. Kaneko,

    1. Department of Applied Chemistry, Graduate School of Engineering, Osaka University, 2-1 Yamadaoka, Suita, 565-0871, Japan
    2. Core Research for Evolutional Science and Technology (CREST), Japan Science and Technology Agency (JST), Kawaguchi Center Building, 4-1-8, Honcho, Kawaguchi, 332-0012, Japan
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  • K. Hamada,

    1. Department of Applied Chemistry, Graduate School of Engineering, Osaka University, 2-1 Yamadaoka, Suita, 565-0871, Japan
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  • M. Q. Chen,

    1. School of Chemical and Material Engineering, Southern Yangtze University, Wuxi 214036, P.R.China
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  • M. Akashi

    1. Department of Applied Chemistry, Graduate School of Engineering, Osaka University, 2-1 Yamadaoka, Suita, 565-0871, Japan
    2. Core Research for Evolutional Science and Technology (CREST), Japan Science and Technology Agency (JST), Kawaguchi Center Building, 4-1-8, Honcho, Kawaguchi, 332-0012, Japan
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  • This work was financially supported by CREST from the Japan Science and Technology Agency and was partly supported by Sekisui Chemical Co. Ltd. Supporting Information is available online from Wiley InterScience or from the author.

Abstract

Freeze-drying of polymeric nanoparticles with projection coronas results in the successful formation of three-dimensional microconstructs with various morphologies, including hollow microspheres (see Figure), without a solid or colloidal template. The microconstructs have sufficient mechanical strength to redisperse successfully in water without collapsing, while they break into nanoparticles following successive freeze–thawing cycles.

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