Biorelevant Calcification and Non-Cytotoxic Behavior in Silicon Nanowires


  • J. L. C. gratefully acknowledges support for this research by the Robert A. Welch Foundation as well as the National Science Foundation. The authors thank Dr. Giridhar R. Akkaraju, Department of Biology, Texas Christian University for assistance with the cell proliferation assays, and Dr. Leigh T. Canham, pSiMedica Ltd., for useful discussions. Supporting Information is available online from Wiley InterScience or from the author.


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Silicon nanowires develop a uniform synthetic bone coating under an electric-field bias in simulated body fluid. The hydroxyapatite-coated nanowires (see Figure) support fibroblast attachment and proliferation, and remain responsive to electrical bias even after coating, providing a system for electric-field modulated tissue regeneration.