Monodisperse Polyelectrolyte-Supported Asymmetric Lipid-Bilayer Vesicles


  • This work was financially supported by the Australian Research Council (ARC) (Discovery Project and Federation Fellowship Schemes), the Victorian State Government (STI Initiative), and the Ministry of Education, Culture, Sports, Science and Technology (MEXT) of Japan (Grant-in-Aid for JSPS Fellow, No. 16·5511). K. K. acknowledges the Japan Society for the Promotion of Science (JSPS) for a Research Fellowship for Young Scientists. The ARC Particulate Fluids and Processing Centre (Melbourne University) is also acknowledged for support.


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Tailored polyelectrolyte-supported asymmetric lipid-bilayer vesicles are prepared by layer-by-layer assembly onto colloidal templates (see Figure). The inner and outer leaflets are composed of different lipids. Both unilamellar and multilamellar lipid coatings are readily prepared by this approach, which may be useful in the construction of artificial cell-membrane models or drug-delivery systems with designed compositions and structures.