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Ferrocene-Functionalized Cationic Polythiophene for the Label-Free Electrochemical Detection of DNA


  • This work was supported by the Natural Sciences and Engineering Research Council of Canada and the Canada Research Chair Program. The authors also thank Dr. Régis Peytavi and Frédéric Raymond for helpful discussions.


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Specific, sensitive detection of unlabeled target DNA at room temperature is reported. A new, water-soluble, ferrocene-functionalized, cationic polythiophene is synthesized. This conducting polymer, used together with gold-bound peptide nucleic acid (PNA) probes, makes, by a simple electrostatic method, DNA detection possible (see Figure).

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