This work was supported by the U.S. Department of Energy (DE-FG-02-01ER45935), the National Science Foundation CARRER Award (ECS-0103430), and partially supported by a NIGMS MBRS SCORE grant (2-S06-GM60654).
Peptide-Based Nanotubes and Their Applications in Bionanotechnology†
Article first published online: 29 AUG 2005
Copyright © 2005 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Volume 17, Issue 17, pages 2037–2050, September, 2005
How to Cite
Gao, X. and Matsui, H. (2005), Peptide-Based Nanotubes and Their Applications in Bionanotechnology. Adv. Mater., 17: 2037–2050. doi: 10.1002/adma.200401849
- Issue published online: 29 AUG 2005
- Article first published online: 29 AUG 2005
- Manuscript Accepted: 15 MAR 2005
- Manuscript Received: 10 NOV 2004
- Molecular recognition;
In nature, biological nanomaterials are synthesized under ambient conditions in a natural microscopic-sized laboratory, such as a cell. Biological molecules, such as peptides and proteins, undergo self-assembly processes in vivo and in vitro, and these monomers are assembled into various nanometer-scale structures at room temperature and atmospheric pressure. The self-assembled peptide nanostructures can be further organized to form nanowires, nanotubes, and nanoparticles via their molecular-recognition functions. The application of molecular self-assemblies of synthetic peptides as nanometer-scale building blocks in devices is robust, practical, and affordable due to their advantages of reproducibility, large-scale production ability, monodispersity, and simpler experimental methods. It is also beneficial that smart functionalities can be added at desired positions in peptide nanotubes through well-established chemical and peptide syntheses. These features of peptide-based nanotubes are the driving force for investigating and developing peptide nanotube assemblies for biological and non-biological applications.