Self-Assembly of Crosslinked DNA–Gold Nanoparticle Layers Visualized by In-Situ Scanning Force Microscopy


  • This work was supported by Deutsche Forschungsgemeinschaft (DFG) through grant Ni399/4-3 and Bundesministerium für Bildung und Forschung (BMBF) through grant 13N8643. We thank Pompi Hazarika for help with the synthesis of the DNA-gold nanoparticles. Supporting Information is available online from Wiley InterScience or from the author.


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Two-dimensional streptavidin crystals are used as the substrate for DNA-directed assembly of crosslinked gold-nanoparticle aggregates (see Figure). As shown by in-situ scanning force microscopy, the interparticle distance can be controlled by the length of the DNA linker connecting individual particles. This system may lead to nanostructured materials with programmable functionalities for use in nanobiotechnology.