This work was supported by the Australian Research Council (Discovery Project and Federation Fellowship schemes) and the Victorian State Government, Department of Innovation, Industry and Regional Development, Science, Technology and Innovation initiative. B. Radt and Q. Li (CNST) are thanked for CLSM and atomic force microscopy measurements.
1521-4095/asset/olbannercenter.gif?v=1&s=529a7434a29cae1cc1d6c7ab89395d70e2677ce1)
Communication
Mesoporous Silica Particles as Templates for Preparing Enzyme-Loaded Biocompatible Microcapsules†
Article first published online: 8 JUL 2005
DOI: 10.1002/adma.200402045
Copyright © 2005 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Additional Information
How to Cite
Yu, A., Wang, Y., Barlow, E. and Caruso, F. (2005), Mesoporous Silica Particles as Templates for Preparing Enzyme-Loaded Biocompatible Microcapsules. Advanced Materials, 17: 1737–1741. doi: 10.1002/adma.200402045
- †
Publication History
- Issue published online: 8 JUL 2005
- Article first published online: 8 JUL 2005
- Manuscript Accepted: 8 MAR 2005
- Manuscript Received: 16 DEC 2004
- Abstract
- References
- Cited By
Keywords:
- Drug delivery;
- Encapsulation;
- Hollow materials;
- Mesoporous materials;
- Nanospheres;
- Polyelectrolytes;
- Self-assembly, layer-by-layer;
- Template-directed assembly/synthesis
Graphical Abstract
Following enzyme adsorption within the pores of mesoporous silica template spheres, polypeptide multilayers are assembled on the particles, and the template is dissolved. This yields a high concentration of enzyme in an active state within the microcapsules (microcapsules are shown in the Figure), which can be released upon changing the pH or salt concentration of the dispersion medium.