Mesoporous Silica Particles as Templates for Preparing Enzyme-Loaded Biocompatible Microcapsules


  • This work was supported by the Australian Research Council (Discovery Project and Federation Fellowship schemes) and the Victorian State Government, Department of Innovation, Industry and Regional Development, Science, Technology and Innovation initiative. B. Radt and Q. Li (CNST) are thanked for CLSM and atomic force microscopy measurements.


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Following enzyme adsorption within the pores of mesoporous silica template spheres, polypeptide multilayers are assembled on the particles, and the template is dissolved. This yields a high concentration of enzyme in an active state within the microcapsules (microcapsules are shown in the Figure), which can be released upon changing the pH or salt concentration of the dispersion medium.