Simple Fabrication of a Highly Sensitive and Fast Glucose Biosensor Using Enzymes Immobilized in Mesocellular Carbon Foam


  • H.K. thanks the National Research Laboratory Program, the Nano Measurement Technology Project of the Ministry of Science and Technology, and the BK21 Program of the Ministry of Education for financial support. T.H. thanks the Korean Ministry of Science and Technology through the National Creative Research Initiative Program for financial support. J.K. thanks the U.S. Department of Energy (DOE) LDRD funds administered by the Pacific Northwest National Laboratory, and the DOE Office of Biological and Environmental Research under the Environmental Management Science Program. The research was performed in part at the W. R. Wiley Environmental Molecular Sciences Laboratory, a national scientific user facility sponsored by the U.S. DOE's Office of Biological and Environmental Research, and located at Pacific Northwest National Laboratory. Supporting Information is available online from Wiley InterScience or from the author. D.L. and J.L. contributed equally to this work.


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Glucose oxidase immobilized in mesocellular carbon foam results in a highly sensitive and fast glucose biosensor. The structure of the mesocellular foam (see Figure), with a combination of mesopores containing the glucose oxidase (GOx) enzymes and micropores and transport channels, results in high enzyme loading and low mass-transfer limitations, producing higher catalytic activity and sensitivity than polymer-matrix-based GOx glucose sensors.