The authors thank Prof. Antonios Mikos for use of his cell culture facilities, Prof. Rena D'Souza for the use of rat pulp cells and Prof. Yongkeun Lee for valuable discussions. We also thank V. Murthy in Prof. Michael Wong's group for assistance with dynamic light scattering. H. W. J. gratefully acknowledges his support by the Peter and Ruth Nicholas Postdoctoral Fellowship. J. D. H. is a recipient of the Searle Scholar Award. This work has been funded in part by a Welch Foundation research grant and by the National Science and Engineering Initiative of the NSF under award #EEC-0118007.
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Communication
Enzyme-Mediated Degradation of Peptide-Amphiphile Nanofiber Networks†
Article first published online: 15 SEP 2005
DOI: 10.1002/adma.200500855
Copyright © 2005 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Additional Information
How to Cite
Jun, H.-W., Yuwono, V., Paramonov, S. E. and Hartgerink, J. D. (2005), Enzyme-Mediated Degradation of Peptide-Amphiphile Nanofiber Networks. Adv. Mater., 17: 2612–2617. doi: 10.1002/adma.200500855
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Publication History
- Issue published online: 25 OCT 2005
- Article first published online: 15 SEP 2005
- Manuscript Accepted: 22 JUN 2005
- Manuscript Received: 25 APR 2005
- Abstract
- References
- Cited By
Keywords:
- Biocompatible materials;
- Hydrogels;
- Proteins;
- Self-assembly;
- Tissue engineering
Peptide-amphiphile nanofibers are prepared that incorporate a peptide sequence permitting enzyme-mediated degradation (see Figure). Cleavage of the peptide sequence results in breakdown of the nanostructure and, consequently, the mechanical properties. This novel elastic nanofiber network is able to encapsulate dental pulp cells, supporting their proliferation and migration, and mimics several key properties of natural extracellular matrix.