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Tailoring Cell Adhesion Using Surface-Grafted Polymer Gradient Assemblies


  • This work was supported by the National Science Foundation, Grants No. CTS-0403535 (GOALI) and EEC-0403903 (NIRT) and the Office of Naval Research. The VASE was purchased with funds awarded to JG through the National Science Foundation's Instrumentation for Materials Research Program, Grant No. DMR-9975780. MC3T3 cells were kindly provided by Dr. Gayle Lester at UNC Chapel Hill and Dr. L. D. Quarles at Duke University. We especially thank Chang Chen for her help with cell culture maintenance and staining.


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Surface-grafted polymer assemblies with a gradient in molecular weight (MW) and/or grafting density (σ) are used to tune protein adsorption, which consequently governs cell adhesion. Increasing the surface coverage of the polymer by increasing the MW and/or σ results in a decrease in the amount of protein adsorbed, which causes a decrease in the number of cells adhered and a change in cell morphology.

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