Surface-Nucleated Assembly of Fibrillar Extracellular Matrices

Authors


  • This work was funded by NSF CAREER (BES-0093226) and the Georgia Tech/Emory NSF ERC on the Engineering of Living Tissues (EEC-9731643). The authors thank J. L. Charest and W. P. King for micropatterning stamps. Supporting Information is available online from Wiley InterScience or from the author.

Abstract

original image

Synthetic surfaces, presenting a covalently immobilized oligopeptide sequence (FN13) from the self-assembly domain of fibronectin (FN), nucleate and template the assembly of robust fibrillar extracellular matrices. These matrices contain fibronectin and type I collagen (COL), as shown in the Figure, and exhibit increased cell-proliferation rates.

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