Surface-Nucleated Assembly of Fibrillar Extracellular Matrices


  • This work was funded by NSF CAREER (BES-0093226) and the Georgia Tech/Emory NSF ERC on the Engineering of Living Tissues (EEC-9731643). The authors thank J. L. Charest and W. P. King for micropatterning stamps. Supporting Information is available online from Wiley InterScience or from the author.


original image

Synthetic surfaces, presenting a covalently immobilized oligopeptide sequence (FN13) from the self-assembly domain of fibronectin (FN), nucleate and template the assembly of robust fibrillar extracellular matrices. These matrices contain fibronectin and type I collagen (COL), as shown in the Figure, and exhibit increased cell-proliferation rates.