The authors acknowledge the support of the National Institutes of Health for this work (CA 5285712, DE 013023, HL 060435).
Electrically Controlled Drug Delivery from Biotin-Doped Conductive Polypyrrole†
Article first published online: 2 MAR 2006
Copyright © 2006 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Volume 18, Issue 5, pages 577–581, March, 2006
How to Cite
George, P. M., LaVan, D. A., Burdick, J. A., Chen, C.-Y., Liang, E. and Langer, R. (2006), Electrically Controlled Drug Delivery from Biotin-Doped Conductive Polypyrrole. Adv. Mater., 18: 577–581. doi: 10.1002/adma.200501242
- Issue published online: 2 MAR 2006
- Article first published online: 2 MAR 2006
- Manuscript Accepted: 1 NOV 2005
- Manuscript Received: 18 JUN 2005
- Drug delivery;
- Electroactive materials;
- Polymeric materials;
- Stimuli-responsive materials
A platform for controlled drug delivery using a conductive-polymer substrate has been created. Through the incorporation of biotin into the conductive polymer polypyrrole (PPy) and the subsequent attachment of the desired drug molecule (such as nerve growth factor, NGF) via a streptavidin linker, an applied potential can trigger release of the drug from the polymer surface (see figure).