Advanced Materials

“Supercritical Carbon Dioxide in Water” Emulsion-Templated Synthesis of Porous Calcium Alginate Hydrogels

Authors


  • We thank the following for technical assistance: Z. Luklinska, R. Whitenstall, and M. Willis (EM unit), V. Ford (CADCAM), J. Caulfield (technical assistance), and Dr. M. Phillips (Experimental officer). N. Houston (Honeywill & Stein) is kindly thanked for supplying the sodium alginate. EPSRC is thanked for an Advanced Research Fellowship (J. A. D., grant no. GR/A11304), for a case award (S. P.), and funding (I. R., IRC core grant and J. R. J., respectively). Lloyds Tercentenary Foundation is thanked for funding (J. R. J.). Supporting Information is available online from Wiley InterScience or from the author.

Abstract

Controlled-porosity alginate hydrogels are synthesized via a novel organic solvent-free method, “reactive emulsion templating”, which utilizes dense-phase carbon dioxide as a reagent and as a templating agent to produce well-defined hydrogels with a narrow macropore-size distribution and high degrees of porosity and interconnectivity (see Figure). These hydrogels may find use in the biomedical field as drug delivery devices, wound dressings, or as supports for tissue engineering applications.

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