Communication

Nanostructured Hydrogels for Three-Dimensional Cell Culture Through Self-Assembly of Fluorenylmethoxycarbonyl–Dipeptides†

  1. V. Jayawarna1,
  2. M. Ali1,
  3. T. A. Jowitt2,
  4. A. F. Miller3,
  5. A. Saiani1,
  6. J. E. Gough1,
  7. R. V. Ulijn1

Article first published online: 2 MAR 2006

DOI: 10.1002/adma.200501522

Issue

Advanced Materials

Advanced Materials

Volume 18, Issue 5, pages 611–614, March, 2006

Additional Information

How to Cite

Jayawarna, V., Ali, M., Jowitt, T. A., Miller, A. F., Saiani, A., Gough, J. E. and Ulijn, R. V. (2006), Nanostructured Hydrogels for Three-Dimensional Cell Culture Through Self-Assembly of Fluorenylmethoxycarbonyl–Dipeptides. Adv. Mater., 18: 611–614. doi: 10.1002/adma.200501522

Author Information

  1. 1

    School of Materials, The University of Manchester, Grosvenor Street, Manchester M1 7HS, UK

  2. 2

    Faculty of Life Sciences, The University of Manchester, Grosvenor Street, Manchester M1 7HS, UK

  3. 3

    School of Chemical Engineering and Analytical Science, The University of Manchester, Grosvenor Street, Manchester M1 7HS, UK

  1. †

    We acknowledge the University of Manchester for the financial support of VJ. We thank Patrick Hill (School of Chemical Engineering and Analytical Science) for help with ESEM and CryoSEM, Karen McKinlay (School of Mechanical, Materials and Manufacturing Engineering, University of Nottingham) for help with ESEM and Robert Fernandez (Faculty of Life Sciences, University of Manchester) for help with confocal and two-photon microscopy.

Publication History

  1. Issue published online: 2 MAR 2006
  2. Article first published online: 2 MAR 2006
  3. Manuscript Accepted: 13 JAN 2006
  4. Manuscript Received: 22 JUL 2005

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Keywords:

  • Biomaterials;
  • Cells;
  • Hydrogels;
  • Peptides;
  • Supramolecular materials;
  • Tissue engineering
Thumbnail image of graphical abstract

A number of short peptide amphiphiles consisting of dipeptides linked to fluorenylmethoxycarbonyl spontaneously form fibrous hydrogels under physiological conditions (see figure). The structural and physical properties of these gels are dictated by the amino acid sequence of the peptide building blocks, and the gels support the three-dimensional cell culture of chondrocytes.

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