Communication

Conducting-Polymer Nanotubes for Controlled Drug Release†

  1. M. R. Abidian2,
  2. D.-H. Kim3,
  3. D. C. Martin1

Article first published online: 25 JAN 2006

DOI: 10.1002/adma.200501726

Issue

Advanced Materials

Advanced Materials

Volume 18, Issue 4, pages 405–409, February, 2006

Additional Information

How to Cite

Abidian, M. R., Kim, D.-H. and Martin, D. C. (2006), Conducting-Polymer Nanotubes for Controlled Drug Release. Adv. Mater., 18: 405–409. doi: 10.1002/adma.200501726

Author Information

  1. 1

    Departments of Materials Science and Engineering, Biomedical Engineering, and Macromolecular Science and Engineering, University of Michigan, H. H. Dow Building Room 2022, Ann Arbor, MI 48109-2136, USA

  2. 2

    Department of Biomedical Engineering, University of Michigan, Ann Arbor, Ann Arbor, MI 48109-2136, USA

  3. 3

    Department of Biomedical Engineering, University of Michigan, Ann Arbor, Ann Arbor, MI 48109-2136, USA

  1. †

    The authors express their appreciation to Matt Meier, David Lin, Prof. Daryl Kipke, and Dr. David Pellinen. Helpful comments on the manuscript were provided by Jeffrey Hendricks, Dr. Sarah Richardson-Burns, and Prof. Michael Mayer. This research was supported by the National Institute of Health (NIH) National Institute of Neurological Disorders and Stroke (NINDS) (NO1-NS-1–2338). Partial support was also provided by the National Science Foundation (DMR-0084 304 and DMR-0518 079), and the NASA Bioscience and Engineering Institute (NBEI). This research was facilitated by the Neural Engineering Laboratory, the Center for Neural Communications Technology, and the Electron Microbeam Analysis Laboratory (EMAL) at the University of Michigan.

Publication History

  1. Issue published online: 10 FEB 2006
  2. Article first published online: 25 JAN 2006
  3. Manuscript Accepted: 4 NOV 2005
  4. Manuscript Received: 18 AUG 2005

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Keywords:

  • Actuation;
  • Biomedical applications;
  • Conducting polymers;
  • Controlled release;
  • Drug delivery;
  • Nanotubes, composite
Thumbnail image of graphical abstract

Controlled release of an anti-inflammatory drug from PEDOT nanotubes using electrical stimulation is demonstrated (see Figure and Inside Cover). The fabrication process includes electrospinning of a biodegradable polymer into which the drug has been incorporated, followed by electrochemical deposition of the conducting polymer around the drug-loaded electrospun nanoscale fibers.

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