Conducting-Polymer Nanotubes for Controlled Drug Release


  • The authors express their appreciation to Matt Meier, David Lin, Prof. Daryl Kipke, and Dr. David Pellinen. Helpful comments on the manuscript were provided by Jeffrey Hendricks, Dr. Sarah Richardson-Burns, and Prof. Michael Mayer. This research was supported by the National Institute of Health (NIH) National Institute of Neurological Disorders and Stroke (NINDS) (NO1-NS-1–2338). Partial support was also provided by the National Science Foundation (DMR-0084 304 and DMR-0518 079), and the NASA Bioscience and Engineering Institute (NBEI). This research was facilitated by the Neural Engineering Laboratory, the Center for Neural Communications Technology, and the Electron Microbeam Analysis Laboratory (EMAL) at the University of Michigan.


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Controlled release of an anti-inflammatory drug from PEDOT nanotubes using electrical stimulation is demonstrated (see Figure and Inside Cover). The fabrication process includes electrospinning of a biodegradable polymer into which the drug has been incorporated, followed by electrochemical deposition of the conducting polymer around the drug-loaded electrospun nanoscale fibers.