A Micropatterned Hydrogel Platform for Chemical Synthesis and Biological Analysis


  • The authors acknowledge VersaMatrix A/S for generous supply of PEGA monomers and the EPSRC for funding through Grant No. GR/T09736/01.


original image

A polymer hydrogel platform for peptide arrays compatible both with solid-phase peptide synthesis (SPPS) conditions and the aqueous environment essential for biological assays is demonstrated. Micropatterning followed by multiple-step peptide synthesis in situ is followed by proof-of-concept on-chip biological assays involving cells and enzymes (see Figure and cover).