This work was supported by the Australian Research Council (Discovery Project and Federation Fellowship Schemes) and the Victorian State Government, Department of Innovation, Industry and Regional Development, Science, Technology and Innovation initiative. The Particulate Fluids Processing Centre is acknowledged for infrastructure support. Christina Cortez is thanked for assistance with CLSM experiments.
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Communication
Nanoporous Protein Particles Through Templating Mesoporous Silica Spheres†
Article first published online: 21 FEB 2006
DOI: 10.1002/adma.200501901
Copyright © 2006 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Additional Information
How to Cite
Wang, Y. and Caruso, F. (2006), Nanoporous Protein Particles Through Templating Mesoporous Silica Spheres. Advanced Materials, 18: 795–800. doi: 10.1002/adma.200501901
- †
Publication History
- Issue published online: 15 MAR 2006
- Article first published online: 21 FEB 2006
- Manuscript Accepted: 25 NOV 2005
- Manuscript Received: 9 SEP 2005
- Abstract
- References
- Cited By
Keywords:
- Drug delivery;
- Nanoparticles, organic;
- Nanoporous materials;
- Proteins;
- Silica, mesoporous;
- Template-directed assembly
Graphical Abstract
Sequential assembly of protein and polyelectrolyte in mesoporous silica (MS) spheres leads to the formation of nanoporous protein particles (NPPs); the MS templates are removed after the fabrication process (see figure). The NPPs based on catalase show excellent biological activity, with up to 57 % of the activity retained. This strategy offers a novel and effective method of preparing bioactive NPPs of diverse composition, particle size, and shape.