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Advanced Materials

Nanoporous Protein Particles Through Templating Mesoporous Silica Spheres


  • This work was supported by the Australian Research Council (Discovery Project and Federation Fellowship Schemes) and the Victorian State Government, Department of Innovation, Industry and Regional Development, Science, Technology and Innovation initiative. The Particulate Fluids Processing Centre is acknowledged for infrastructure support. Christina Cortez is thanked for assistance with CLSM experiments.


Sequential assembly of protein and polyelectrolyte in mesoporous silica (MS) spheres leads to the formation of nanoporous protein particles (NPPs); the MS templates are removed after the fabrication process (see figure). The NPPs based on catalase show excellent biological activity, with up to 57 % of the activity retained. This strategy offers a novel and effective method of preparing bioactive NPPs of diverse composition, particle size, and shape.

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