“Fish-in-Net” Encapsulation of Enzymes in Macroporous Cages for Stable, Reusable, and Active Heterogeneous Biocatalysts


  • We thank Prof. Dezheng Wang of Tsinghua University, Zhi-Ming Qiu of Changchun Institute of Applied Chemistry, Lan Zhao, Da-Liang Zhang, and Prof. Dazheng Jiang of Jilin University for helpful suggestions and discussions. This work is supported by NSFC, BASF, CNPC, the National High Technology Research and Development Program of China (863 Program), State Basic Research Project (973 Program 2004CB217804 and 2003CB615807), and the Ministry of Education of China.


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Various enzymes are encapsulated in ordered mesoporous silica analogous to a fish in a net, where the enzymes are entrapped in macroporous cages that are connected by uniform mesoporous channels (see Figure). Most importantly, these encapsulated enzymes act as nanoreactors, showing not only comparable activities with native enzymes, but also excellent long-term recycling stabilities.