Niels Akeroyd is thanked for the synthesis of p(HPMA-DMAE). Kevin Braeckmans helped through processing the confocal images. Heleen Devenijn is thanked for practical assistance. Oliver Kreft is thanked for helpful discussions. Ghent University is thanked for a BOF scholarship. N. S. is a Postdoctoral Fellow of the Fund for Scientific Research—Flanders (Belgium).
Intracellularly Degradable Polyelectrolyte Microcapsules†
Article first published online: 21 MAR 2006
Copyright © 2006 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Volume 18, Issue 8, pages 1005–1009, April, 2006
How to Cite
De Geest, B. G., Vandenbroucke, R. E., Guenther, A. M., Sukhorukov, G. B., Hennink, W. E., Sanders, N. N., Demeester, J. and De Smedt, S. C. (2006), Intracellularly Degradable Polyelectrolyte Microcapsules. Adv. Mater., 18: 1005–1009. doi: 10.1002/adma.200502128
- Issue published online: 7 APR 2006
- Article first published online: 21 MAR 2006
- Manuscript Accepted: 5 DEC 2005
- Manuscript Received: 6 OCT 2005
- Drug delivery;
- Layer-by-layer assembly;
- Template-directed assembly/synthesis
Intracellular uptake and degradation of polyelectrolyte capsules is reported in this work. Two types of intracellular degradable capsules are described: enzyme-sensitive and hydrolysis- sensitive capsules (see figure). The results may be a significant step towards the biomedical application of polyelectrolyte capsules.