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Intracellularly Degradable Polyelectrolyte Microcapsules

Authors

  • B. G. De Geest,

    1. Laboratory of General Biochemistry and Physical Pharmacy, Faculty of Pharmaceutical Sciences, Ghent University, Harelbekestraat 72, 9000 Ghent, Belgium
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  • R. E. Vandenbroucke,

    1. Laboratory of General Biochemistry and Physical Pharmacy, Faculty of Pharmaceutical Sciences, Ghent University, Harelbekestraat 72, 9000 Ghent, Belgium
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  • A. M. Guenther,

    1. Max Planck Institute of Colloids & Interfaces, Am Muehlenberg 1, 14476 Potsdam, Germany
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  • G. B. Sukhorukov,

    1. Max Planck Institute of Colloids & Interfaces, Am Muehlenberg 1, 14476 Potsdam, Germany
    2. IRC/Materials, Queen Mary University of London, Mile End Road, E1 4NS London, UK
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  • W. E. Hennink,

    1. Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, P.O. Box 800082, 3508 TB Utrecht, The Netherlands
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  • N. N. Sanders,

    1. Laboratory of General Biochemistry and Physical Pharmacy, Faculty of Pharmaceutical Sciences, Ghent University, Harelbekestraat 72, 9000 Ghent, Belgium
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  • J. Demeester,

    1. Laboratory of General Biochemistry and Physical Pharmacy, Faculty of Pharmaceutical Sciences, Ghent University, Harelbekestraat 72, 9000 Ghent, Belgium
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  • S. C. De Smedt

    1. Laboratory of General Biochemistry and Physical Pharmacy, Faculty of Pharmaceutical Sciences, Ghent University, Harelbekestraat 72, 9000 Ghent, Belgium
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  • Niels Akeroyd is thanked for the synthesis of p(HPMA-DMAE). Kevin Braeckmans helped through processing the confocal images. Heleen Devenijn is thanked for practical assistance. Oliver Kreft is thanked for helpful discussions. Ghent University is thanked for a BOF scholarship. N. S. is a Postdoctoral Fellow of the Fund for Scientific Research—Flanders (Belgium).

Abstract

Intracellular uptake and degradation of polyelectrolyte capsules is reported in this work. Two types of intracellular degradable capsules are described: enzyme-sensitive and hydrolysis- sensitive capsules (see figure). The results may be a significant step towards the biomedical application of polyelectrolyte capsules.

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