In Vivo Magnetic Resonance Imaging of Single-Walled Carbon Nanohorns by Labeling with Magnetite Nanoparticles

Authors

  • J. Miyawaki,

    1. SORST, Japan Science and Technology Agency, c/o NEC Corporation, 34 Miyukigaoka, Tsukuba, Ibaraki 305-8501, Japan
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  • M. Yudasaka,

    1. SORST, Japan Science and Technology Agency, c/o NEC Corporation, 34 Miyukigaoka, Tsukuba, Ibaraki 305-8501, Japan
    2. Fundamental and Environmental Research Laboratories, NEC Corporation, 34 Miyukigaoka, Tsukuba, Ibaraki 305-8501, Japan
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  • H. Imai,

    1. Fundamental and Environmental Research Laboratories, NEC Corporation, 34 Miyukigaoka, Tsukuba, Ibaraki 305-8501, Japan
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  • H. Yorimitsu,

    1. Department of Chemistry, The University of Tokyo, Hongo, Bunkyo, Tokyo 113-0033, Japan
    2. Present address: Department of Materials Chemistry, Kyoto University, Nishikyo, Kyoto 615-8510, Japan
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  • H. Isobe,

    1. Department of Chemistry, The University of Tokyo, Hongo, Bunkyo, Tokyo 113-0033, Japan
    2. Also with ERATO, Japan Science and Technology Agency
    3. Also with PRESTO, Japan Science and Technology Agency
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  • E. Nakamura,

    1. Department of Chemistry, The University of Tokyo, Hongo, Bunkyo, Tokyo 113-0033, Japan
    2. Also with ERATO, Japan Science and Technology Agency
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  • S. Iijima

    1. SORST, Japan Science and Technology Agency, c/o NEC Corporation, 34 Miyukigaoka, Tsukuba, Ibaraki 305-8501, Japan
    2. Fundamental and Environmental Research Laboratories, NEC Corporation, 34 Miyukigaoka, Tsukuba, Ibaraki 305-8501, Japan
    3. Present address: Department of Materials Chemistry, Kyoto University, Nishikyo, Kyoto 615-8510, Japan
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  • We thank Dr. Takeshi Azami and Dr. Daisuke Kasuya for preparing the SWNHs and thank Dr. Kiyotaka Shiba and Dr. Tatsuya Murakami for their advice. We also thank BioView Co. and Varian Technologies Japan Ltd. for their experimental support during the NMR and MRI measurements. Financial support from Monbukagakusho, Japan (the 21st Century COE Program for Frontiers in Fundamental Chemistry and Nanobio COE) is gratefully acknowledged (E. N. and H. I.). Supporting Information is available online from Wiley InterScience or from the author.

Abstract

original image

Nanoparticles of superparamagnetic magnetite have been strongly attached to single-walled carbon nanohorns (SWNHs) by using a simple method, namely the deposition of iron acetate clusters on SWNHs followed by heat treatment. The attached magnetite nanoparticles induce remarkable darkening of the magnetic resonance images, which allowed in vivo visualization (see figure) of the accumulative behavior of SWNHs in the spleen and kidneys.

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