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Advanced Materials

Rapid-Setting, Mesoporous, Bioactive Glass Cements that Induce Accelerated In Vitro Apatite Formation

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  • This work was supported by the MRSEC Program of the National Science Foundation under Award No. DMR05-20415 and by the Office of Naval Research under Grant No. N00014-04-1-0654. Supporting Information is available online from Wiley InterScience or from the author.

Abstract

A rapid-setting, mesoporous, bioactive glass cement (MBGC, see figure) that exhibits highly desirable plasticity and superior in vitro bioactivity is described. The calcium-deficient hydroxyapatite nanocrystals that form during cement setting act as linkers between mesoporous bioactive glass particles to make the cement mechanically robust. The MGBC is promising for applications in clinical orthopedics, drug delivery, and tissue engineering.

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