Acellular Synthesis of a Human Enamel-like Microstructure


  • This investigation was supported by a USPHS Research Grant DE015599 from the National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892. The JEOL-2010F SEM/TEM used for this investigation was funded by a National Science Foundation Grant DMR-9871177. Supporting information is available online from Wiley InterScience or from the author.


original image

A mild hydrothermal process is used as a direct method to produce synthetic human enamel prism-like structures that are biocompatible with dental pulp stem cells. The rod-like fluorapatite crystals are very similar in chemical composition and in structural dimensions to natural tooth enamel (see figure).