Nanoscale Engineering of Biomaterial Surfaces


  • This work was supported in part from grants from the US National Institutes of Health (R24 AI-47739-03), the National Science Foundation, the Nanotechnology Institute through the Ben–Franklin Technology Partners of Northeastern Pennsylvania, Vanderbilt Institute for Integrative Biosystems Research and Education (VIIBRE), and an NSF IGERT Fellowship to AML. The authors wish to thank Nancy Schultz from 3M for kindly providing us with the Ruby Red pressure-sensitive tape in order to carry out the ASTM adhesion tests and Jay Sy for the scanning electron microscope image of the ASTM peel test. Supporting Information is available online from Wiley InterScience or from the author.


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Single-step independent modification of the texture and chemistry of a material surface through the assembly of functionalized silica nanoparticles (NPs) is described. Such NP surface modifications enhance the differentiation of human-marrow-derived mesenchymal cells into an osteogenic lineage and present a new paradigm for nanoscale biomimetic engineering of a biomaterial surface.