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Enhanced Aldol Reaction Using an Aldolase I Antibody Immobilized in 3D Mesoporous Silica Foam

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Abstract

3D foamlike mesoporous silica with ca. 16 nm pore size (see figure) has been used to immobilize aldolase antibody 84G3. This immobilization results in significantly accelerated and stable aldol reactions at similar selectivities (>98 % ee) compared to those of the free antibody.

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