Using a Core–Sheath Distribution of Surface Chemistry through 3D Tissue Engineering Scaffolds to Control Cell Ingress


  • We thank Rachel Wilson, Dr. Felicity Rose, Dr. Pauline Lee, Mr. P. A. Fields, and Mr. R. G. Wilson for their help and advice. We thank the EPSRC for financial support (J. J. A. B., SRIF funding and the EPSRC grant (GR/R47851/01) to purchase and run the XPS instrument housed in the School of Chemistry, University of Nottingham). S. M. H. is a Royal Society Wolfson Research Merit Award Holder. Sven Tougaard is acknowledged for his help in using the QUASES program to analyze the N1s background shape. Supporting Information is available online from Wiley InterScience or from the author.


original image

A core/sheath distribution of cell-adhesive and non-cell-adhesive surface coatings is produced in porous biodegradable poly(D,L-lactic acid) discs using sequential plasma polymerization. The figure and cover show an X-ray micro-computed tomography image of a section of a 10 mm diameter, 4 mm thick scaffold where fibroblast cells (shown in red) have been encouraged by the surface chemistry to penetrate to the scaffold core.