Rapid, Room-Temperature Formation of Crystalline Calcium Molybdate Phosphor Microparticles via Peptide-Induced Precipitation


  • This research was supported by the Air Force Office of Scientific Research (Dr. J. Fuller, Dr. H. C. De Long, program managers) and the Office of Naval Research (Dr. M. Spector). Supporting information is available online from Wiley InterScience or from the authors.


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A phage display method has been used for the first time to identify peptides that bind to, and induce the rapid formation of, a pure crystalline binary metal oxide compound, CaMoO4, at room temperature from a soluble aqueous precursor solution (see figure). This demonstration opens the door to the biosculpting (peptide patterning, then localized peptide-induced mineralization) of functional synthetic crystalline multicomponent compounds onto or with low-temperature or chemically dissimilar materials.