Nano- to Microscale Porous Silicon as a Cell Interface for Bone-Tissue Engineering


  • The authors thank April Frankenberg for the isolation of primary osteoblasts, Barbara Stroyer for the preparation of immunofluorescence, and Jack Calcines for the help on AFM imaging. Supporting Information is available online from Wiley InterScience or from the author.


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Porous Si (PSi) is shown to support and promote primary osteoblast growth (shown in the figure), protein-matrix synthesis, and mineralization. It is also shown that the osteoconductivity of PSi and other cellular responses can be controlled by altering the micro-/ nanoarchitecture of the porous interface. This material has the potential to be a functional biomaterial with both osteoconductivity and drug- delivery functions.