Triple-Helix Scaffolds of Grafted Collagen Reinforced by Al2O3–ZrO2 Nanoparticles


  • We gratefully acknowledge the National Science Fund for Distinguished Young Scholars (20 325 518) and Creative Research Groups (20 521 503), the Key Program (20 535 010), General Program (50 377 005) of the National Natural Science Foundation of China, and the Program for New Century Excellent Talents in University ‘NCET-04-0482' from the Ministry of Education of China for financial support of this research.


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The triple-helix structure of grafted collagen is reinforced with bimetallic Al2O3–ZrO2 nanoparticles (see figure), thereby significantly improving the mechanical and thermal stability of the polymer matrix. The stability of this hybrid nanocomposite is thought to derive from the chemical bonding between the surface oxygen atoms on the nanoparticles and functional groups on the collagen matrix. The improved and robust collagen bioscaffolds may potentially be useful for bionic and biomedical applications.