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Advanced Materials

Ultrasound-Triggered Smart Drug Release from a Poly(dimethylsiloxane)– Mesoporous Silica Composite

Authors

  • H.-J. Kim,

    1. Nano-energy Materials Group, Energy Technology Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Umezono 1-1-1, Tsukuba, Ibaraki 305-8568, Japan
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  • H. Matsuda,

    1. Nano-energy Materials Group, Energy Technology Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Umezono 1-1-1, Tsukuba, Ibaraki 305-8568, Japan
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  • H. Zhou,

    1. Nano-energy Materials Group, Energy Technology Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Umezono 1-1-1, Tsukuba, Ibaraki 305-8568, Japan
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  • I. Honma

    1. Nano-energy Materials Group, Energy Technology Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Umezono 1-1-1, Tsukuba, Ibaraki 305-8568, Japan
    2. Nano Surface Technology Team, Korea Institute of Industrial Technology (KITECH), Songdo-dong 7-47, Incheon 406-800, Korea
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  • Supporting Information is available online from Wiley InterScience or from the author.

Abstract

Ultrasound is used as an external trigger for the pulsatile release of the drug ibuprofen. The system is composed of mesoporous silica as the drug reservoir and poly(dimethylsiloxane) (PDMS) as an implantable body. This system could find use for in vivo delivery of drugs in response to changes in physiological conditions.

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