A Combinatorial Library of Photocrosslinkable and Degradable Materials


  • We are grateful to the National Institutes of Health for funding (grants K22DE015761, R01 DE016516). K. J. V. V. and C. A. T. gratefully acknowledge partial funding from the DuPont-MIT Alliance, the National Science Foundation Graduate Fellowship program (C. A. T.), and use of the experimental facilities in the Center for Materials Science and Engineering supported by the National Science Foundation under award number DMR 02-13282. Supporting Information is available online from Wiley InterScience or from the author.


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A library of acrylate-terminated poly(β-amino ester)s is synthesized in parallel (see figure and inside cover) via a condensation reaction that combines primary or secondary amines with diacrylates. This library of macromers is then photopolymerized to form networks with a wide range of degradation and mechanical properties. Because of the diversity in properties, these polymers could be developed and screened for numerous applications ranging from microdevices to biomaterials.