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Targeting and Uptake of Multilayered Particles to Colorectal Cancer Cells

Authors


  • C. Cortez and E. Tomaskovic-Cook contributed equally to this work. This work was supported by the Australian Research Council under the Federation Fellowship (F. C.) and Discovery Project (F. C., C. C., A. P. R. J., B. R.) schemes, and by the Victorian State Government under the STI Initiative. E. T.-C. was supported by a National Health and Medical Research Council (NHMRC) of Australia Dora Lush Postgraduate Research Scholarship. E. C. N. and A. M. S. were supported, in part, by the NHMRC Project Grants 191500, 164809, and 164814, and Program Grant 164802. Supporting Information is available online from Wiley InterScience or from the author.

Abstract

Core/shell particles and capsules formed by a layer-by-layer technique are biofunctionalized with a humanized A33 monoclonal antibody (huA33 mAb) that binds to the A33 antigen present on colorectal cancer cells (see figure). Targeting to a colorectal cancer cell line shows selective binding and internalization of particles.

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