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DNA Designer Defects in Photonic Crystals: Optically Monitored Biochemistry

Authors

  • F. Fleischhaker,

    1. Materials Chemistry Research Group, Chemistry Department, University of Toronto, 80 St. George Street, Toronto, ON M5S 3H6, Canada
    2. Institute of Organic Chemistry, Department of Chemistry and Pharmacy, University of Mainz, Duesbergweg 10–14, 55128 Mainz, Germany
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  • A. C. Arsenault,

    1. Materials Chemistry Research Group, Chemistry Department, University of Toronto, 80 St. George Street, Toronto, ON M5S 3H6, Canada
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  • F. C. Peiris,

    1. Materials Chemistry Research Group, Chemistry Department, University of Toronto, 80 St. George Street, Toronto, ON M5S 3H6, Canada
    2. On leave from Department of Physics, Kenyon College, Gambier, OH 43022, USA
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  • V. Kitaev,

    1. Materials Chemistry Research Group, Chemistry Department, University of Toronto, 80 St. George Street, Toronto, ON M5S 3H6, Canada
    2. Present address: Department of Chemistry, Wilfrid Laurier University, 75 University Ave. W, Waterloo, N2L 3C5, Canada
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  • I. Manners,

    1. Materials Chemistry Research Group, Chemistry Department, University of Toronto, 80 St. George Street, Toronto, ON M5S 3H6, Canada
    2. Present address: School of Chemistry, University of Bristol, Cantock's Close, Bristol BS8 1TS, UK
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  • R. Zentel,

    1. Institute of Organic Chemistry, Department of Chemistry and Pharmacy, University of Mainz, Duesbergweg 10–14, 55128 Mainz, Germany
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  • G. A. Ozin

    1. Materials Chemistry Research Group, Chemistry Department, University of Toronto, 80 St. George Street, Toronto, ON M5S 3H6, Canada
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  • G. A. O and I. M. are Government of Canada Research Chairs in Materials and Polymer Chemistry. F. F and A. C. A thank the “Fonds der chemischen Industrie” and NSERC, respectively, for graduate scholarships. Many thanks are due to Dr. Georg v. Freymann for providing the SWA-simulation program. The authors are grateful to NSERC, the University of Toronto, and the DFG for financial assistance.

Abstract

original image

Biomolecules have been incorporated as designed planar defect layers in colloidal photonic crystals using self- assembly techniques (see figure). Through shifts of the photonic intragap defect mode, for example, DNA conformational changes and the enantioselective intercalation of a chiral anticancer drug can be optically monitored. This newfound capability for optically monitoring biochemistry bodes well for the development of a new generation of simple on-the-spot color readout biosensors.

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