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Advanced Materials

Three-Dimensional Biochemical and Biomechanical Patterning of Hydrogels for Guiding Cell Behavior


  • The authors thank the NIH and NSF for funding. They also thank Kyriacos Athanasiou and Adrian Shieh for nanoindentation data, and Melissa McHale for help with the cell culture and with critical review of the manuscript.


The ability to spatially tailor material biomechanical and biochemical properties at the microscale and to create freeform 3D patterns and gradients within existing photoactive networks (see figure) is demonstrated. The ability of patterned substrates to guide cell migration is also shown.

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