Cationic Supramolecules Composed of Multiple Oligoethylenimine-Grafted β-Cyclodextrins Threaded on a Polymer Chain for Efficient Gene Delivery


  • This work was financially supported by the Ministry of Education (MOE) and the Agency for Science, Technology and Research (A*STAR), Singapore. Supporting Information is available online from Wiley InterScience or from the author.


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Cationic supramolecules composed of multiple oligoethylenimine-grafted β-cyclodextrins that are threaded and blocked on a triblock copolymer chain (see figure) are synthesized as gene-delivery vectors. The supramolecules contain many cationic cyclic units threaded on a polymer chain to form an integrated entity, functioning as a macromolecular gene vector with good DNA binding ability, low cytotoxicity, and high gene-transfection efficiency.