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Keywords:

  • Cyclodextrins;
  • DNA;
  • Gene delivery;
  • Polymers;
  • Rotaxanes;
  • Supramolecular materials
Thumbnail image of graphical abstract

Cationic supramolecules composed of multiple oligoethylenimine-grafted β-cyclodextrins that are threaded and blocked on a triblock copolymer chain (see figure) are synthesized as gene-delivery vectors. The supramolecules contain many cationic cyclic units threaded on a polymer chain to form an integrated entity, functioning as a macromolecular gene vector with good DNA binding ability, low cytotoxicity, and high gene-transfection efficiency.