This work was financially supported by the Ministry of Education (MOE) and the Agency for Science, Technology and Research (A*STAR), Singapore. Supporting Information is available online from Wiley InterScience or from the author.
Cationic Supramolecules Composed of Multiple Oligoethylenimine-Grafted β-Cyclodextrins Threaded on a Polymer Chain for Efficient Gene Delivery†
Article first published online: 27 OCT 2006
Copyright © 2006 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Volume 18, Issue 22, pages 2969–2974, November, 2006
How to Cite
Li, J., Yang, C., Li, H., Wang, X., Goh, S. H., Ding, J. L., Wang, D. Y. and Leong, K. W. (2006), Cationic Supramolecules Composed of Multiple Oligoethylenimine-Grafted β-Cyclodextrins Threaded on a Polymer Chain for Efficient Gene Delivery. Adv. Mater., 18: 2969–2974. doi: 10.1002/adma.200600812
- Issue published online: 14 NOV 2006
- Article first published online: 27 OCT 2006
- Manuscript Revised: 11 AUG 2006
- Manuscript Received: 13 APR 2006
- Ministry of Education (MOE)
- Agency for Science, Technology and Research (A*STAR)
- Gene delivery;
- Supramolecular materials
Cationic supramolecules composed of multiple oligoethylenimine-grafted β-cyclodextrins that are threaded and blocked on a triblock copolymer chain (see figure) are synthesized as gene-delivery vectors. The supramolecules contain many cationic cyclic units threaded on a polymer chain to form an integrated entity, functioning as a macromolecular gene vector with good DNA binding ability, low cytotoxicity, and high gene-transfection efficiency.