Biocompatible, Hydrophilic, Supramolecular Carbon Nanoparticles for Cell Delivery


  • Financial support was provided by the National Science Foundation (CTS-0342844 and NIRT grant DMI-0506661), NIEHS grant R01 ES03721, NRSA grant F30 ES013639 and the NIEHS-supported Superfund Basic Research Program at Brown University (P42 ES013660). The authors thank Kengqing Jian, Matthew Sousa, Michel Paukschto, Paula Weston, and Professor Gregory Crawford at Brown University for technical contributions and/or sample donation, and Graheme Williams of Brookhaven Instruments Corporation for the zeta-potential measurement.


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Liquid-crystal self-assembly is used to fabricate carbon nanoparticles specially suited for cell-delivery applications (see figure). The nanoparticles possess high-activity surfaces for easy functionalization and aqueous dispersion, and are shown to be rapidly internalized by mesothelial cells, wherein they show no measurable toxicity relative to crystalline silica used as a positive control.